Lithium neurotoxicity at subtherapeutic serum levels
نویسندگان
چکیده
منابع مشابه
Lithium neurotoxicity at normal serum levels.
Case Report A 61-year-old man with history of bipolar disorder that was managed with lithium for more than 20 years presented with complaints of psychomotor slowdown, unsteady gait, memory deficits, restlessness, sleep disorder, and severe tremor in his hand that prevented him from eating or drinking properly. These symptoms had begun in the previous week. There was no recent history of fever, ...
متن کاملLithium Neurotoxicity at ‘therapeutic’ Levels a Case Report
A case of a young manic patient who developed severe neurotoxicity when on lithium alone has been presented. Investigations did not reveal presence of any infection, electrolyte imbalance or rise in lithium level.The possibility of lithium producing neurotoxicity at therapeutic levels for as yet unknown reasons is pointed out. It is suggested that this element of risk be considered when startin...
متن کاملLithium neurotoxicity.
The peripheral and central neurotoxic effects of lithium carbonate are illustrated by 4 case histories. Lithium neurotoxicity is likely to be more common than the literature suggests. Neurological sequelae may be irreversible and may be associated with therapeutic serum levels. Prevention may be facilitated by more stringent case selection, EEG and clinical monitoring and the development of imp...
متن کاملLithium neurotoxicity.
Inspite of the advent of newer antimanic drugs, lithium carbonate remains widely used in the treatment and prevention of manic-depressive illness. However care has to be exercised due to its low therapeutic index. The central nervous system and renal system are predominantly affected in acute lithium intoxication and is potentially lethal. The more common side effect involves the central nervou...
متن کاملPathological Neurotoxicity with Lithium
Though lithium-induced neurotoxicity usually occurs when serum lithium exceeds 2.0 mEq/1, reports document its occurrence with serum lithium within the therapeutic range (Strayhorn and Nash 1977, Hansen and Amidsen, 1978, Speirs and Hirsch 1978, West and Meltzer 1979). Neurotoxicity has even been described with serum lithium between 0.4 and 0.5 mEq/1 (Hansen and Amidsen 1978). Such may best be ...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1994
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.164.1.123a